Come celebrate the new graduate students and post-docs in the Polymer Group! All members and faculty welcome!

An integrative approach to nanomedicine: new tools for drug delivery

Nanoparticle translation to the clinic is lacking in large part due to limited accumulation in tumor

sites. This can be attributed to the complexity and heterogeneity of both the biological

environment and the nanoparticle constructs, making it prohibitively challenging to deconvolute

individual factors that contribute to nanoparticle trafficking and accumulation. We have developed

integrated screening approaches to gain a holistic understanding of both the nanomaterials

properties and biological features mediating successful drug delivery. By leveraging combinatorial

libraries of polymer and lipid-based nanoparticles and pooled cell screening, we can begin to

establish structure-function relationships at the nano-bio interface. In this talk, I will describe our

nanoparticle library design and synthesis and the results from our integrated screens, which

indicate that matching nanoparticle properties and cellular phenotypes is much more critical for

targeted delivery than previously thought.

Come learn about how to navigate job offers and aspects to consider when signing employment contracts!

Our panelists include:

• David Dingwell, Plakas Mannos

• Dr. Nicholas Ball-Jones, Boston Scientific